Inhibitors of Microglial Neurotoxicity: Focus on Natural Products
نویسندگان
چکیده
منابع مشابه
Inhibitors of microglial neurotoxicity: focus on natural products.
Microglial cells play a dual role in the central nervous system as they have both neurotoxic and neuroprotective effects. Uncontrolled and excessive activation of microglia often contributes to inflammation-mediated neurodegeneration. Recently, much attention has been paid to therapeutic strategies aimed at inhibiting neurotoxic microglial activation. Pharmacological inhibitors of microglial ac...
متن کاملNatural products as angiogenesis inhibitors.
Angiogenesis is a strictly controlled process in the healthy, adult human body. It is regulated by a variety of endogenous angiogenic and angiostatic factors. It is only switched on, e.g., during wound healing. Pathological angiogenesis occurs, for example, in cancer, chronic inflammation, or atherosclerosis. Angiogenesis inhibitors are able to interfere with various steps of angiogenesis, like...
متن کاملIdentifying HER2 Inhibitors from Natural Products Database
The relationship between abnormal HER2 expression and cancer is important in cancer therapeutics. Formation and spread of cancer cells may be restricted by inhibiting HER2. We conducted ligand-based and structure-based studies to assess the potency of natural compounds as potential HER2 inhibitors. Multiple linear regression (MLR) and support vector machine (SVM) models were constructed to pred...
متن کاملSynthetic studies on electron transport inhibitors related to natural products.
8. Keon, J. 1’. H., White, G. A. and Hargreaves, J. A. (1991) Curr. Genet. 19,475-481 9. Hargreaves, J. A. and Turner, G. (1992) in Molecular Plant Pathology: A Practical Approach, Vol. 1 (Gurr. S. J., McPherson, M. J. and Howles, D. J., eds), pp. 79-97, IRI, Press, Oxford 10. H a d , F.-U., I’fanner, N., Nicholson, D. W. and Neupert, W. (1989) Hiochem. Hiophys. Acta 988, 1-45 11. Hroomfield, P...
متن کاملManganese Neurotoxicity: a Focus on Glutamate Transporters
Manganese (Mn) is an essential element that is required in trace amount for normal growth, development as well maintenance of proper function and regulation of numerous cellular and biochemical reactions. Yet, excessive Mn brain accumulation upon chronic exposure to occupational or environmental sources of this metal may lead to a neurodegenerative disorder known as manganism, which shares simi...
متن کاملذخیره در منابع من
با ذخیره ی این منبع در منابع من، دسترسی به آن را برای استفاده های بعدی آسان تر کنید
ژورنال
عنوان ژورنال: Molecules
سال: 2011
ISSN: 1420-3049
DOI: 10.3390/molecules16021021